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Article

The effect of survival bias on case-control genetic association studies of highly lethal diseases.

Circulation. Cardiovascular genetics - 1 Apr 2011

Anderson Christopher D, Nalls Michael A, Biffi Alessandro, Rost Natalia S, Greenberg Steven M, Singleton Andrew B, Meschia James F, Rosand Jonathan

Abstract excerpt

BACKGROUND: Survival bias is the phenomenon by which individuals are excluded from analysis of a trait because of mortality related to the expression of that trait. In genetic association studies, variants increasing risk for disease onset as well as risk of disease-related mortality (lethality) could be difficult to detect in genetic association case-control designs, possibly leading to underestimation of a...

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Identifiers

PMID: 21292865
DOI: 10.1161/CIRCGENETICS.110.957928
PMCID: PMC3080449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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