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Article

Functional EGFR germline polymorphisms may confer risk for EGFR somatic mutations in non-small cell lung cancer, with a predominant effect on exon 19 microdeletions.

Cancer research - 1 Apr 2011

Liu Wanqing, He Lijun, Ramírez Jacqueline, Krishnaswamy Soundararajan, Kanteti Rajani, Wang Yi-Ching, Salgia Ravi, Ratain Mark J

Abstract excerpt

Somatic mutations in the EGFR tyrosine kinase domain play a critical role in the development and treatment of non-small cell lung cancer (NSCLC). Strong genetic influence on susceptibility to these mutations has been suggested. To identify the genetic factors conferring risk for the EGFR tyrosine kinase mutations in NSCLC, a case-control study was conducted in 141 Taiwanese NSCLC patients by focusing on three...

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Identifiers

PMID: 21292812
DOI: 10.1158/0008-5472.CAN-10-2689
PMCID: PMC3070854

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EGFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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