Article
Prophylactic surgery in Lynch syndrome.
Techniques in coloproctology - 1 Jun 2011
Celentano V, Luglio G, Antonelli G, Tarquini R, Bucci L
Abstract excerpt
Lynch syndrome (LS) is caused by a germline mutations in DNA mismatch repair genes and is a dominantly inherited syndrome, responsible for 2-5% of all colorectal cancer (CRC) cases. Mutation carriers have a 60-85% risk of developing CRC. With the increasing use of genetic predisposition testing, patients and health care providers must decide on cancer risk-reduction strategies. The cancers observed in families...
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