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Prevention of cardiomyopathy in -sarcoglycan knockout mice after systemic transfer of targeted adeno-associated viral vectors

13 Feb 2009

Abstract excerpt

AIMS: Delta-sarcoglycan is a member of the dystrophin-associated glycoprotein complex linking the cytoskeleton to the extracellular matrix. Similar to patients with defects in the gene encoding delta-sarcoglycan (Sgcd), knockout mice develop cardiomyopathy and muscular dystrophy. The aim of our study was to develop an approach for preventing cardiomyopathy in Sgcd-deficient mice by cardiac expression of the...

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PMID: 19218289
DOI: 10.1093/cvr/cvp061

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