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Article

The adapter protein APPL1 links FSH receptor to inositol 1,4,5-trisphosphate production and is implicated in intracellular Ca(2+) mobilization.

Endocrinology - 1 Apr 2011

Thomas Richard M, Nechamen Cheryl A, Mazurkiewicz Joseph E, Ulloa-Aguirre Alfredo, Dias James A

Abstract excerpt

FSH binds to its receptor (FSHR) on target cells in the ovary and testis, to regulate oogenesis and spermatogenesis, respectively. The signaling cascades activated after ligand binding are extremely complex and have been shown to include protein kinase A, mitogen-activated protein kinase, phosphatidylinositol 3-kinase/protein kinase B, and inositol 1,4,5-trisphosphate-mediated calcium signaling pathways. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21285318
DOI: 10.1210/en.2010-1353
PMCID: PMC3060640

Genes

FSHR
APPL1

Variants

Provenance

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