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Article

Genetic analysis of Hedgehog signaling in ventral body wall development and the onset of omphalocele formation.

PloS one - 20 Jan 2011

Matsumaru Daisuke, Haraguchi Ryuma, Miyagawa Shinichi, Motoyama Jun, Nakagata Naomi, Meijlink Frits, Yamada Gen

Abstract excerpt

BACKGROUND: An omphalocele is one of the major ventral body wall malformations and is characterized by abnormally herniated viscera from the body trunk. It has been frequently found to be associated with other structural malformations, such as genitourinary malformations and digit abnormalities. In spite of its clinical importance, the etiology of omphalocele formation is still controversial. Hedgehog (Hh)...

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PMID: 21283718
DOI: 10.1371/journal.pone.0016260
PMCID: PMC3024424

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