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Article

Genetic analysis of the role of Alx4 in the coordination of lower body and external genitalia formation.

European journal of human genetics : EJHG - 1 Mar 2014

Matsumaru Daisuke, Haraguchi Ryuma, Moon Anne M, Satoh Yoshihiko, Nakagata Naomi, Yamamura Ken-ichi, Takahashi Naoki, Kitazawa Sohei, Yamada Gen

Abstract excerpt

Although several syndromes include abnormalities of both the ventral body wall and external genitalia, the developmental bases of this correlation are largely unknown. Naturally occurring mutations in Aristaless-like 4 (Alx4, Strong's luxoid: Alx4Lst) have ventral body wall and pelvic girdle abnormalities. We sought to determine whether the development of the genital tubercle (GT) and its derivatives, the...

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Identifiers

PMID: 23942202
DOI: 10.1038/ejhg.2013.160
PMCID: PMC3925283

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