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Article

An intronic polypyrimidine-rich element downstream of the donor site modulates cystic fibrosis transmembrane conductance regulator exon 9 alternative splicing.

The Journal of biological chemistry - 23 Apr 2004

Zuccato Elisabetta, Buratti Emanuele, Stuani Cristiana, Baralle Francisco E, Pagani Franco

Abstract excerpt

Two intronic elements, a polymorphic TGmTn locus at the end of intron 8 and an intronic splicing silencer in intron 9, regulate aberrant splicing of human cystic fibrosis transmembrane conductance regulator (CFTR) exon 9. Previous studies (Pagani, F., Buratti, E., Stuani, C., Romano, M., Zuccato, E., Niksic, M., Giglio, L., Faraguna, D., and Baralle, F. E. (2000) J. Biol. Chem. 275, 21041-21047 and Buratti, E.,...

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PMID: 14966131
DOI: 10.1074/jbc.M313439200

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CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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Related research

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An intronic polypyrimidine-rich element downstream of the donor site modulates cystic fibrosis transmembrane conductance regulator exon 9 alternative splicing.PMID 14966131Read ↗

Regulation of the mutually exclusive exons 8a and 8 in the CaV1.2 calcium channel transcript by polypyrimidine tract-binding protein.Semantic proximity Read ↗

Atypical 5' splice sites cause CFTR exon 9 to be vulnerable to skipping.Semantic proximity Read ↗

Nuclear Factor TDP-43 Binds to the Polymorphic TG Repeats in CFTR Intron 8 and Causes Skipping of Exon 9: A Functional Link with Disease PenetranceSemantic proximity Read ↗

Splicing Factors Induce Cystic Fibrosis Transmembrane Regulator Exon 9 Skipping through a Nonevolutionary Conserved Intronic ElementSemantic proximity Read ↗

A variable dinucleotide repeat in the CFTR gene contributes to phenotype diversity by forming RNA secondary structures that alter splicing.Semantic proximity Read ↗

A T3 allele in the CFTR gene exacerbates exon 9 skipping in vas deferens and epididymal cell lines and is associated with Congenital Bilateral Absence of Vas Deferens (CBAVD).Semantic proximity Read ↗

Characterization of disease-associated mutations affecting an exonic splicing enhancer and two cryptic splice sites in exon 13 of the cystic fibrosis transmembrane conductance regulator gene.Semantic proximity Read ↗

Characterization of a disease-associated mutation affecting a putative splicing regulatory element in intron 6b of the cystic fibrosis transmembrane conductance regulator (CFTR) gene.Semantic proximity Read ↗

Identification of an 11T allele in the polypyrimidine tract of intron 8 of the CFTR gene.Semantic proximity Read ↗

Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9.Semantic proximity Read ↗

Functional Analysis of cis-Acting Elements Regulating the Alternative Splicing of Human CFTR Exon 9Semantic proximity Read ↗

Nuclear factor TDP‐43 and SR proteins promote in vitro and in vivo CFTR exon 9 skippingSemantic proximity Read ↗

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