Deep sequencing of GDF5 reveals the absence of rare variants at this important osteoarthritis susceptibility locus.

doi:10.1016/j.joca.2011.01.014

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Deep sequencing of GDF5 reveals the absence of rare variants at this important osteoarthritis susceptibility locus.

Osteoarthritis and cartilage - 1 Apr 2011

Dodd A W, Rodriguez-Fontenla C, Calaza M, Carr A, Gomez-Reino J J, Tsezou A, Reynard L N, Gonzalez A, Loughlin J

Abstract excerpt

OBJECTIVE: The common single nucleotide polymorphism (SNP) rs143383 in the 5' untranslated region (5'UTR) of growth and differentiation factor 5 (GDF5) is strongly associated with osteoarthritis (OA) and influences GDF5 allelic expression in vitro and in the joint tissues of OA patients. This effect is modulated in cis by another common SNP, also located within the 5'UTR, whilst a common SNP in the 3'UTR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Greece

Share to Growth Differentiation Factor 5

Share to High-Throughput Nucleotide Sequencing

Share to Osteoarthritis

Share to Spain

Share to United Kingdom

Source

Open in PubMed

Identifiers

PMID: 21281725
DOI: 10.1016/j.joca.2011.01.014

Genes

GDF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deep sequencing of GDF5 reveals the absence of rare variants at this important osteoarthritis susceptibility locus.PMID 21281725Read ↗

A rare variant in the osteoarthritis-associated locus GDF5 is functional and reveals a site that can be manipulated to modulate GDF5 expression.Semantic proximity Read ↗

An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage.Semantic proximity Read ↗

Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism.Semantic proximity Read ↗

The growth differentiation factor 5 (GDF5) core promoter polymorphism is not associated with knee osteoarthritis in the Greek population.Semantic proximity Read ↗

The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance.Semantic proximity Read ↗

A comprehensive meta-analysis of association between genetic variants of GDF5 and osteoarthritis of the knee, hip and hand.Semantic proximity Read ↗

A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis.Semantic proximity Read ↗

Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation.Semantic proximity Read ↗

The identification of trans-acting factors that regulate the expression of GDF5 via the osteoarthritis susceptibility SNP rs143383.Semantic proximity Read ↗

The association of growth differentiation factor 5 rs143383 gene polymorphism with osteoarthritis: a systematic review and meta-analysis.Semantic proximity Read ↗

A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility.Semantic proximity Read ↗

Rs143383 in the growth differentiation factor 5 (GDF5) gene significantly associated with osteoarthritis (OA)-a comprehensive meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.