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Article

Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells

16 Aug 2004

Abstract excerpt

INTRODUCTION: Notch signaling has been implicated in the regulation of cell-fate decisions such as self-renewal of adult stem cells and differentiation of progenitor cells along a particular lineage. Moreover, depending on the cellular and developmental context, the Notch pathway acts as a regulator of cell survival and cell proliferation. Abnormal expression of Notch receptors has been found in different types...

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PMID: 15535842
DOI: 10.1186/bcr920

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