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Heterogeneity of breast cancer stem cells as evidenced with <scp>N</scp>otch‐dependent and <scp>N</scp>otch‐independent populations

18 Jul 2012

Abstract excerpt

Studies have suggested the potential importance of Notch signaling to the cancer stem cell population in some tumors, but it is not known whether all cells in the cancer stem cell fraction require Notch activity. To address this issue, we blocked Notch activity in MCF-7 cells by expressing a dominant-negative MAML-GFP (dnMAML) construct, which inhibits signaling through all Notch receptors, and quantified the...

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PMID: 23342261
DOI: 10.1002/cam4.18

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