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Article

Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors.

Pharmacogenetics and genomics - 1 May 2011

Mirza Nasir S, Alfirevic Ana, Jorgensen Andrea, Marson Anthony G, Pirmohamed Munir

Abstract excerpt

OBJECTIVE: Carbonic anhydrase (CA) inhibitors topiramate and zonisamide can induce metabolic acidosis in some patients. Our aims were to assess the prevalence and severity of this acidosis and to determine its predictors. METHODS: For 70 patients established on treatment with topiramate (n=55) or zonisamide (n=14) or both (n=1), we measured electrolytes, and genotyped single nucleotide polymorphisms (SNPs) in the...

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PMID: 21278619
DOI: 10.1097/FPC.0b013e3283441b95

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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