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Article

Epistasis between FSHR and CYP19A1 polymorphisms is associated with premature ovarian failure.

Fertility and sterility - 30 Jun 2011

Kim Sunshin, Pyun Jung-A, Cha Dong Hyun, Ko Jeong-Jae, Kwack KyuBum

Abstract excerpt

Follicle-stimulating hormone secreted from the pituitary gland plays a key role in human reproduction and regulates estrogen production by acting on the regulatory region of CYP19A1. We observed a significant association between premature ovarian failure and the combined genetic effect of single nucleotide polymorphism (SNP) rs4646 (CA+AA) in the 3' untranslated region of CYP19A1 and the missense FSHR SNP rs6166...

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Source

Identifiers

PMID: 21269619
DOI: 10.1016/j.fertnstert.2010.12.042

Genes

FSHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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