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Article

Epistasis between CYP19A1 and ESR1 polymorphisms is associated with premature ovarian failure.

Fertility and sterility - 1 Jan 2011

Kim Sunshin, Pyun Jung-A, Kang HyunJun, Kim JiHye, Cha Dong Hyun, Kwack KyuBum

Abstract excerpt

Because an interaction between CYP19A1 and ESR1 may play a key role in determining the level of circulating E2 by way of the hypothalamus-hypophysis-ovarian axis, the effect of single nucleotide polymorphism (SNP)-SNP interactions between CYP19A1 and ESR1 on the development of premature ovarian failure (POF) was investigated by comparing the polymorphisms of 98 patients with POF and 218 matched controls of Korean...

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Source

Identifiers

PMID: 20797716
DOI: 10.1016/j.fertnstert.2010.07.1067

Genes

ESR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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