Article
Genetic polymorphisms of the DNA repair gene UNG are associated with the susceptibility of rheumatoid arthritis.
Rheumatology international - 1 Dec 2012
Lo Sui-Foon, Wan Lei, Huang Chung-Ming, Lin Hsiu-Chen, Chen Shih-Yin, Liu Su-Ching, Tsai Fuu-Jen
Abstract excerpt
The involvement of uracil-DNA glycosylase (UNG) in the pathogenesis of cancer is well documented. In contrast, the role of this protein in rheumatoid arthritis (RA) development is not well defined, although previous studies suggest a possible link between autoimmune diseases and malignancy. Therefore, we aimed to examine whether there is a link between UNG genetic polymorphisms and RA. Our present study...
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