Article
Association of the C-285T and A5954G polymorphisms in the DNA repair gene OGG1 with the susceptibility of rheumatoid arthritis.
Rheumatology international - 1 May 2012
Chen Shih-Yin, Wan Lei, Huang Chung-Ming, Huang Yu-Chuen, Sheu Jim Jinn-Chyuan, Lin Ying-Ju, Liu Shih-Ping, Lan Yu-Ching, Lai Chih-Ho, Lin Cheng-Wen, Tsai Chang-Hai, Tsai Fuu-Jen
Abstract excerpt
Rheumatoid arthritis (RA) is a chronic autoimmune disease and can lead to deformities and severe disabilities, due to irreversible damage of tendons, joints, and bones. Previous study indicated that DNA repair system was involved in the pathology of RA. In this study, we investigated the association of two 8-oxoguanine glycosylase 1 (OGG1) gene polymorphisms (rs159153 and rs3219008) with the susceptibility to RA...
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