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Article

Association study of cannabinoid receptor 1 (CNR1) gene in tardive dyskinesia.

The pharmacogenomics journal - 1 Jun 2012

Tiwari A K, Zai C C, Likhodi O, Voineskos A N, Meltzer H Y, Lieberman J A, Potkin S G, Remington G, Müller D J, Kennedy J L

Abstract excerpt

Tardive dyskinesia (TD) is a severe, debilitating movement disorder observed in 25-30% of the patients treated with typical antipsychotics. Cannabinoid receptor 1 (CNR1) activators tend to inhibit movement, an effect prevented by rimonabant and other selective CNR1 antagonists. Furthermore, CNR1 receptor is downregulated in Huntington's disease and upregulated in Parkinson's disease. Twenty tagSNPs spanning the...

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Source

Identifiers

PMID: 21266946
DOI: 10.1038/tpj.2010.93

Genes

CNR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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