Article
Association study between the neurexin-1 gene and tardive dyskinesia.
Human psychopharmacology - 1 Jan 2017
Lanning Rachel, Lett Tristram A, Tiwari Arun K, Brandl Eva J, de Luca Vincenzo, Voineskos Aristotle N, Potkin Steven G, Lieberman Jeffrey A, Meltzer Herbert Y, Müller Daniel J, Remington Gary, Kennedy James L, Zai Clement C
Abstract excerpt
OBJECTIVE: Tardive dyskinesia (TD) is a motor side effect that may develop after long-term antipsychotic treatment. Schizophrenia has recently been associated with the Neurexin-1 (NRXN1) gene that codes for a cell adhesion molecule in synaptic communication. METHODS: This study examined five NRXN1 single-nucleotide polymorphisms (SNPs) for possible association with the occurrence and severity of TD in 178...
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