Article
Epidermal Growth Factor Receptor (EGFR) mutation analysis, gene expression profiling and EGFR protein expression in primary prostate cancer.
BMC cancer - 25 Jan 2011
Peraldo-Neia Caterina, Migliardi Giorgia, Mello-Grand Maurizia, Montemurro Filippo, Segir Raffaella, Pignochino Ymera, Cavalloni Giuliana, Torchio Bruno, Mosso Luciano, Chiorino Giovanna, Aglietta Massimo
Abstract excerpt
BACKGROUND: Activating mutations of the epidermal growth factor receptor (EGFR) confer sensitivity to the tyrosine kinase inhibitors (TKi), gefitinib and erlotinib. We analysed EGFR expression, EGFR mutation status and gene expression profiles of prostate cancer (PC) to supply a rationale for EGF...
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