Article
Targeting EGFR in bladder cancer.
World journal of urology - 1 Dec 2007
Villares G J, Zigler M, Blehm K, Bogdan C, McConkey D, Colin D, Bar-Eli Menashe
Abstract excerpt
Expression and overexpression of the epidermal growth factor receptor (EGFR) have been described in several solid tumors including bladder, breast, colorectal, NSCLC, prostate, and ovarian cancers. In addition to gene amplification, point mutations within the kinase domain also occur. Previous reports indicate that the patient's response to gefitinib depends on either the presence of mutations within the kinase...
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