Article
Clinical significance of epidermal growth factor receptor protein overexpression and gene copy number gains in prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2007
Schlomm Thorsten, Kirstein Patrick, Iwers Liv, Daniel Birte, Steuber Thomas, Walz Jochen, Chun Felix H K, Haese Alexander, Kollermann Jens, Graefen Markus, Huland Hartwig, Sauter Guido, Simon Ronald, Erbersdobler Andreas
Abstract excerpt
PURPOSE: The epidermal growth factor receptor (EGFR) is a protein involved in the tumor progression of many cancer types and is an important therapeutic target. To determine its role in prostate cancer, we analyzed 2,497 prostate cancers on the DNA and protein level. EXPERIMENTAL DESIGN: Tissue s...
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