Article
Monitoring the long-term molecular epidemiology of the pneumococcus and detection of potential 'vaccine escape' strains.
PloS one - 10 Jan 2011
Pandya Gagan A, McEllistrem M Catherine, Venepally Pratap, Holmes Michael H, Jarrahi Behnam, Sanka Ravi, Liu Jia, Karamycheva Svetlana A, Bai Yun, Fleischmann Robert D, Peterson Scott N
Abstract excerpt
BACKGROUND: While the pneumococcal protein conjugate vaccines reduce the incidence in invasive pneumococcal disease (IPD), serotype replacement remains a major concern. Thus, serotype-independent protection with vaccines targeting virulence genes, such as PspA, have been pursued. PspA is comprised of diverse clades that arose through recombination. Therefore, multi-locus sequence typing (MLST)-defined clones...
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