Article
Neonatal leptin administration alters regional brain volumes and blocks neonatal growth restriction-induced behavioral and cardiovascular dysfunction in male mice.
Pediatric research - 1 May 2011
Erkonen Gwen E, Hermann Gregory M, Miller Rachel L, Thedens Daniel L, Nopoulos Peg C, Wemmie John A, Roghair Robert D
Abstract excerpt
Premature delivery is often complicated by neonatal growth restriction (GR) and neurodevelopmental impairment. Because global overnutrition increases the risk of adult metabolic syndrome, we sought a targeted intervention. Premature delivery and perinatal GR decrease circulating levels of the neurotrophic hormone leptin. We hypothesized that leptin supplementation would normalize the outcomes of mice with...
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