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Article

Metyrapone alleviates deleterious effects of maternal food restriction on lung development and growth of rat offspring.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Feb 2015

Paek David S, Sakurai Reiko, Saraswat Aditi, Li Yishi, Khorram Omid, Torday John S, Rehan Virender K

Abstract excerpt

Maternal food restriction (MFR) causes intrauterine growth restriction, a known risk factor for developing chronic lung disease. However, it is unknown whether this negative outcome is gender specific or preventable by blocking the MFR-induced hyperglucocorticoidism. Using a well-established rat model, we used metyrapone (MTP), an inhibitor of glucocorticoid synthesis, to study the MFR-induced lung changes on...

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Identifiers

PMID: 24916330
DOI: 10.1177/1933719114537712
PMCID: PMC4287596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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