Article
Evolving methods for single nucleotide polymorphism detection: Factor V Leiden mutation detection.
Journal of clinical laboratory analysis - 1 Jan 2011
Oh Herin, Smith Cassandra L
Abstract excerpt
BACKGROUND: The many techniques used to diagnose the Factor V Leiden (FVL) mutation, the most common hereditary hypercoagulation disorder in Eurasians, and the most frequently requested genetic test reflect the evolving strategies in protein and DNA diagnosis. METHODS: Here, molecular methods to diagnose the FVL mutation are discussed. RESULTS: Protein-based detection assays include the conventional functional...
Topics
- Blood Coagulation Tests
- DNA Mutational Analysis
- Factor V
- Humans
- Immunoassay
- Molecular Diagnostic Techniques
- Mutation
- Oligonucleotide Array Sequence Analysis
- Polymorphism, Restriction Fragment Length