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Article

Platelet protein kinase C-theta deficiency with human RUNX1 mutation: PRKCQ is a transcriptional target of RUNX1.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2011

Jalagadugula Gauthami, Mao Guangfen, Kaur Gurpreet, Dhanasekaran Danny N, Rao A Koneti

Abstract excerpt

OBJECTIVE: Mutations in the hematopoietic transcription factor RUNX1 cause thrombocytopenia and impaired platelet function. In a patient with a heterozygous mutation in RUNX1, we have described decreased platelet pleckstrin phosphorylation and protein kinase C- (PKC-, gene PRKCQ) associated with thrombocytopenia, impaired platelet aggregation, and dense granule secretion. Little is known regarding regulation of...

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Source

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Identifiers

PMID: 21252065
DOI: 10.1161/ATVBAHA.110.221879
PMCID: PMC3066073

Genes

RUNX1
PRKCQ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Platelet protein kinase C-theta deficiency with human RUNX1 mutation: PRKCQ is a transcriptional target of RUNX1.PMID 21252065Read ↗

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