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Article

Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation

3 Nov 2017

Abstract excerpt

as a RUNX1 target gene and revealed a previously unappreciated role of NOTCH4 signaling in promoting human megakaryopoiesis. Our work suggests that human iPSCs with monogenic mutations have the potential to serve as an invaluable resource for discovery of novel druggable targets.

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Identifiers

PMID: 29101237
DOI: 10.1182/blood-2017-04-780379

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