Article
Molecular spectrum of β-thalassemia in Fujian Province, Southeastern China.
Hemoglobin - 1 Jan 2013
Huang Hailong, Xu Liangpu, Lin Na, He Deqin, Li Yin, Guo Danhua, Wang Linshuo, Wang Yan, Zhen Lin, Xu Jinbang, Lin Yuan
Abstract excerpt
To provide basic information for β-thalassemia (β-thal) screening, genetic counseling and prenatal diagnosis (PND), we characterized β-thal mutations in Fujian Province, Southeastern China. A total of 16 different β-thal gene mutations were identified from 1058 patients. Of these, the IVS-II-654 (C>T) and codons 41/42 (-TCTT) were the most prevalent, accounting for 76.3% of the total mutations. Six gene...
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