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Article

Characterization of Subtypes of BRAF-Mutant Papillary Thyroid Cancer Defined by Their Thyroid Differentiation Score.

The Journal of clinical endocrinology and metabolism - 24 Mar 2022

Boucai Laura, Seshan Venkatraman, Williams Michelle, Knauf Jeffrey A, Saqcena Mahesh, Ghossein Ronald A, Fagin James A

Abstract excerpt

CONTEXT: The BRAFV600E mutation has been associated with more advanced clinical stage in papillary thyroid cancer (PTC) and decreased responsiveness to radioiodine (RAI). However, some BRAF mutant PTCs respond to RAI and have an indolent clinical behavior suggesting the presence of different subtypes of BRAF mutant tumors with distinct prognosis. OBJECTIVE: To characterize the molecular and clinical features of 2...

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Source

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Identifiers

PMID: 34897468
DOI: 10.1210/clinem/dgab851
PMCID: PMC8947218

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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