Article
MEPE activated by furin promotes pulpal cell adhesion.
Journal of dental research - 1 Apr 2011
Wang H G, Kawashima N, Iwata T, Xu J, Takahashi S, Sugiyama T, Suda H
Abstract excerpt
UNLABELLED: Matrix extracellular phosphoglycoprotein (MEPE) is predominantly expressed in osteoblasts, osteocytes, and odontoblasts and plays key biological roles in bone and dentin metabolism. Post-translational modifications are essential for its activation. This study tested the hypothesis that MEPE is activated through proteolytic processing by furin in dental pulp. MEPE was present in three sizes, 1...
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