Article

Inhibition of soluble epoxide hydrolase induces POTCs to enhance the dentin-pulp complex regeneration mediated by crosstalk between vascular endothelial cells and dental pulp stem cells

2023-09-26

Abstract excerpt

<title>Abstract</title> <p>Background Revascularization and restoration of normal pulp-dentin complex are important for tissue-engineered pulp regeneration. Recently, a unique periodontal tip-like endothelial cells subtype (POTCs) specialized to dentinogenesis was identified. We have confirmed that TPPU, a soluble epoxide hydrolase (sEH) inhibitor targeting EETs metabolism, promotes bone growth and regeneration...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: abe17821-0f2a-52af-8338-b85cfe73b94c
DOI: 10.21203/rs.3.rs-3188410/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibition of soluble epoxide hydrolase induces POTCs to enhance the dentin-pulp complex regeneration mediated by crosstalk between vascular endothelial cells and dental pulp stem cellsDOI 10.21203/rs.3.rs-3188410/v1Read

Exosomes Derived from Dental Pulp Stem Cells Accelerate Cutaneous wound Healing by Enhancing Angiogenesis via Cdc42/p38 MAPK PathwaySemantic proximity Read

Dentin matrix protein 1 and HUVEC-ECM scaffold promote the differentiation of human dental pulp stem cells into endothelial lineage: implications in regenerative medicineSemantic proximity Read

Exosomes Derived from Human Dental Pulp Stem Cells Increase Flap Survival with Ischemia-Reperfusion InjuriesSemantic proximity Read

Exosomes From LPS-stimulated hDPSCs Promote the Angiogenesis of HUVECsSemantic proximity Read

Analysis of the characteristics and expression profiles of coding and noncoding RNAs of human dental pulp stem cells in hypoxic conditionsSemantic proximity Read

Human CD24+ dental papilla cells are highly competent seed cells for dentin-pulp regeneration via BMP2/SIRT1 metabolic axisSemantic proximity Read

Role of MiR-424 on Angiogenic Potential in Human Dental Pulp CellsSemantic proximity Read

Endothelial Cells Promote Osteogenesis by Establishing a Functional and Metabolic Coupling With Human Mesenchymal Stem CellsSemantic proximity Read

Oxidative Stress Induced Endothelial Cells-Derived Exosomes Accelerate Skin Flap Survival Through Lnc NEAT1-Mediated Promotion of Endothelial Progenitor Cell FunctionSemantic proximity Read

Characterization of a new target to human dental pulp regeneration through the identification of PP1 interactomeSemantic proximity Read

TUG1 enhances high gluose impaired endothelial progenitor cell function via miR-29c-3p/PDGF-BB/Wnt signalingSemantic proximity Read

Semaphorin-4D Signaling in Recruiting Dental Stem Cells for Vascular StabilizationSemantic proximity Read