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Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status

19 Mar 2014

Abstract excerpt

BACKGROUND: The aim was to assess and compare prognostic power of nine breast cancer gene signatures (Intrinsic, PAM50, 70-gene, 76-gene, Genomic-Grade-Index, 21-gene-Recurrence-Score, EndoPredict, Wound-Response and Hypoxia) in relation to ER status and follow-up time. METHODS: A gene expression dataset from 947 breast tumors was used to evaluate the signatures for prediction of Distant Metastasis Free Survival...

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PMID: 24645668
DOI: 10.1186/1471-2407-14-211

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