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Article

Lack of trehalose accelerates H2O2-induced Candida albicans apoptosis through regulating Ca2+ signaling pathway and caspase activity.

PloS one - 5 Jan 2011

Lu Hui, Zhu ZhenYu, Dong LingLing, Jia XinMing, Sun XuanRong, Yan Lan, Chai YiFeng, Jiang YuanYing, Cao YingYing

Abstract excerpt

Trehalose is a non-reducing disaccharide and can be accumulated in response to heat or oxidative stresses in Candida albicans. Here we showed that a C. albicans tps1Δ mutant, which is deficient in trehalose synthesis, exhibited increased apoptosis rate upon H(2)O(2) treatment together with an inc...

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Identifiers

PMID: 21246042
DOI: 10.1371/journal.pone.0015808
PMCID: PMC3016397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21246042-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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