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Article

PI4P and Rab inputs collaborate in myosin-V-dependent transport of secretory compartments in yeast.

Developmental cell - 18 Jan 2011

Santiago-Tirado Felipe H, Legesse-Miller Aster, Schott Daniel, Bretscher Anthony

Abstract excerpt

Cell polarity involves transport of specific membranes and macromolecules at the right time to the right place. In budding yeast, secretory vesicles are transported by the myosin-V Myo2p to sites of cell growth. We show that phosphatidylinositol 4-phosphate (PI4P) is present in late secretory compartments and is critical for their association with, and transport by, Myo2p. Further, the trans-Golgi network Rab...

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Share to Cell Compartmentation
Share to Cell Polarity
Share to Golgi Apparatus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Membranes

Share to Myosin Type V

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Share to rab GTP-Binding Proteins

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Source

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Identifiers

PMID: 21238924
DOI: 10.1016/j.devcel.2010.11.006
PMCID: PMC3025538

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

PI4P and Rab inputs collaborate in myosin-V-dependent transport of secretory compartments in yeast.PMID 21238924Read ↗

Direct interaction between a myosin V motor and the Rab GTPases Ypt31/32 is required for polarized secretion.Semantic proximity Read ↗

Complex formation with Ypt11p, a rab-type small GTPase, is essential to facilitate the function of Myo2p, a class V myosin, in mitochondrial distribution in Saccharomyces cerevisiae.Semantic proximity Read ↗

The yeast phosphatidylinositol-4-OH kinase pik1 regulates secretion at the Golgi.Semantic proximity Read ↗

Kinesin-related Smy1 enhances the Rab-dependent association of myosin-V with secretory cargo.Semantic proximity Read ↗

The p21-activated protein kinase-related kinase Cla4 is a coincidence detector of signaling by Cdc42 and phosphatidylinositol 4-phosphate.Semantic proximity Read ↗

The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarity.Semantic proximity Read ↗

A phosphatidylinositol-transfer protein and phosphatidylinositol-4-phosphate 5-kinase control Cdc42 to regulate the actin cytoskeleton and secretory pathway in yeast.Semantic proximity Read ↗

Interaction of the endocytic scaffold protein Pan1 with the type I myosins contributes to the late stages of endocytosis.Semantic proximity Read ↗

Osh4p is needed to reduce the level of phosphatidylinositol-4-phosphate on secretory vesicles as they mature.Semantic proximity Read ↗

Nucleocytoplasmic shuttling of the Golgi phosphatidylinositol 4-kinase Pik1 is regulated by 14-3-3 proteins and coordinates Golgi function with cell growth.Semantic proximity Read ↗

Regulation of Gic2 localization and function by phosphatidylinositol 4,5-bisphosphate during the establishment of cell polarity in budding yeast.Semantic proximity Read ↗

The COOH-terminal domain of Myo2p, a yeast myosin V, has a direct role in secretory vesicle targeting.Semantic proximity Read ↗

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