Article
Aldosterone synthase inhibitors in uncontrolled and resistant hypertension: A phenotype-stratified systematic review and network meta-analysis of randomized trials.
PloS one - 1 Jan 2026
Yusuf Ismaila Ajayi, Badero Olurotimi J, Ihesiulo Alozie, Okwah Micah Nnabuko, Oshodin Abieyuwa, Asikong Emmanuella
Abstract excerpt
BACKGROUND: Aldosterone synthase inhibitors (ASIs) have emerged as a mechanistically targeted strategy for resistant and uncontrolled hypertension; however, no head-to-head trials exist, and comparative efficacy and safety remain uncertain. We compared their efficacy and safety using network and pairwise meta-analysis of randomized trials. METHODS: This systematic review and meta-analysis adhered to the PRISMA...
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