Article
A phenotype-based genetic association study reveals the contribution of neuregulin1 gene variants to age of onset and positive symptom severity in schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2011
Papiol Sergi, Begemann Martin, Rosenberger Albert, Friedrichs Heidi, Ribbe Katja, Grube Sabrina, Schwab Markus H, Jahn Henriette, Gunkel Stefan, Benseler Fritz, Nave Klaus-Armin, Ehrenreich Hannelore
Abstract excerpt
By pure endpoint diagnosis of the disease, the risk of developing schizophrenia has been repeatedly associated with specific variants of the neuregulin1 (NRG1) gene. However, the role of NRG1 in the etiology of schizophrenia has remained unclear. Since Nrg1 serves vital functions in early brain d...
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