Article
Support for NRG1 as a susceptibility factor for schizophrenia in a northern Swedish isolated population.
Archives of general psychiatry - 1 Aug 2009
Alaerts Maaike, Ceulemans Shana, Forero Diego, Moens Lotte N, De Zutter Sonia, Heyrman Lien, Lenaerts An-Sofie, Norrback Karl-Fredrik, De Rijk Peter, Nilsson Lars-Göran, Goossens Dirk, Adolfsson Rolf, Del-Favero Jurgen
Abstract excerpt
CONTEXT: Neuregulin 1 (NRG1), a growth factor involved in neurodevelopment, myelination, neurotransmitter receptor expression, and synaptic plasticity, first joined the list of candidate genes for schizophrenia when a 7-marker haplotype at the 5' end of the gene (Hap(ICE)) was shown to be associated with the disorder in the Icelandic population. Since then, more genetic and functional evidence has emerged, which...
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