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<i>HMGA2</i> Overexpression-Induced Ovarian Surface Epithelial Transformation Is Mediated Through Regulation of EMT Genes

11 Jan 2011

Abstract excerpt

The AT-hook transcription factor HMGA2 is an oncogene involved in the tumorigenesis of many malignant neoplasms. HMGA2 overexpression is common in both early and late-stage high-grade ovarian serous papillary carcinoma. To test whether HMGA2 participates in the initiation of ovarian cancer and promotion of aggressive tumor growth, we examined the oncogenic properties of HMGA2 in ovarian surface epithelial (OSE)...

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PMID: 21224353
DOI: 10.1158/0008-5472.can-10-2550

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<i>HMGA2</i> Overexpression-Induced Ovarian Surface Epithelial Transformation Is Mediated Through Regulation of EMT GenesPMID 21224353Read ↗

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