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Article

Glutathione peroxidase 1 Pro198Leu variant contributes to the metabolic syndrome in men in a large Japanese cohort.

The American journal of clinical nutrition - 1 Jun 2008

Kuzuya Masafumi, Ando Fujiko, Iguchi Akihisa, Shimokata Hiroshi

Abstract excerpt

BACKGROUND: There has been much interest in the role of free radicals and oxidative stress in the pathogenesis of metabolic syndrome (MetS). Cellular antioxidant enzymes such as glutathione peroxidase 1 (GPX1) play a central role in the control of reactive oxygen species. OBJECTIVE: We examined whether GPX1 polymorphism (Pro198Leu) is associated with MetS as well as with each component of MetS. DESIGN: The study...

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Source

Identifiers

PMID: 18541588
DOI: 10.1093/ajcn/87.6.1939

Genes

GPX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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