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DNA repair and apoptosis: Roles in radiotherapy-related acute reactions in breast cancer patients.

Cellular and molecular biology (Noisy-le-Grand, France) - 31 Mar 2018

Batar Bahadir, Mutlu Tuba, Bostanci Merve, Akin Mustafa, Tuncdemir Matem, Bese Nuran, Guven Mehmet

Abstract excerpt

Normal tissue reactions are therapy limiting factor for the effectiveness of the radiotherapy in cancer patients. DNA repair and apoptosis are estimated to be critical players of adverse effects in response to radiotherapy. Our aim was to define the association of DNA repair (ERCC1 and XPC) and apoptotic (BCL2, CASP3 and NFKB1) gene expression, DNA damage levels, apoptosis changes and DNA repair gene variations...

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8-Hydroxy-2'-Deoxyguanosine
Carcinoma, Ductal
Carcinoma, Lobular
Deoxyguanosine
DNA Fragmentation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Situ Nick-End Labeling

Micronucleus Tests

NF-kappa B p50 Subunit

Source

Identifiers

PMID: 29631685

Genes

ERCC1
XPC
BCL2
CASP3
NFKB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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