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Article

A novel TLR3 inhibitor encoded by African swine fever virus (ASFV)

3 Jan 2011

Abstract excerpt

African swine fever virus (ASFV) encodes proteins that manipulate important host antiviral mechanisms. Bioinformatic analysis of the ASFV genome revealed ORF I329L, a gene without any previous functional characterization as a possible inhibitor of TLR signaling. We demonstrate that ORF I329L encodes a highly glycosylated protein expressed in the cell membrane and on its surface. I329L also inhibited...

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PMID: 21203785
DOI: 10.1007/s00705-010-0894-7

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