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Mitochondrial proteomic approach reveals galectin-7 as a novel BCL-2 binding protein in human cells

3 Feb 2011

Abstract excerpt

Although the anti-apoptotic activity of Bcl-2 has been extensively studied, its mode of action remains incompletely understood. Deciphering the network of Bcl-2 interacting factors is necessary to better understand the key function of Bcl-2 in apoptosis initiation. To identify novel Bcl-2 mitochondrial partners, we have combined a Bcl-2 immunocapture with a mass spectrometry analysis using highly pure...

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PMID: 21289092
DOI: 10.1091/mbc.e10-06-0534

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