Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bcr/Abl Interferes with the Fanconi Anemia/BRCA Pathway: Implications in the Chromosomal Instability of Chronic Myeloid Leukemia Cells

28 Dec 2010

Abstract excerpt

Chronic myeloid leukemia (CML) is a malignant clonal disorder of the hematopoietic system caused by the expression of the BCR/ABL fusion oncogene. Although it is well known that CML cells are genetically unstable, the mechanisms accounting for this genomic instability are still poorly understood. Because the Fanconi anemia (FA) pathway is believed to control several mechanisms of DNA repair, we investigated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Chronic Lymphocytic Leukemia Research
Share to Chronic Myeloid Leukemia Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21203397
DOI: 10.1371/journal.pone.0015525

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bcr/Abl Interferes with the Fanconi Anemia/BRCA Pathway: Implications in the Chromosomal Instability of Chronic Myeloid Leukemia CellsPMID 21203397Read ↗

BCR-ABL: a multi-faceted promoter of DNA mutation in chronic myelogeneous leukemia.Semantic proximity Read ↗

Genomic instability: The cause and effect of BCR/ABL tyrosine kinase.Semantic proximity Read ↗

Chromosome Instability in Fanconi Anemia: From Breaks to Phenotypic ConsequencesSemantic proximity Read ↗

BCR-ABL down-regulates the DNA repair protein DNA-PKcsSemantic proximity Read ↗

Leukemia and chromosomal instability in aged Fancc−/− miceSemantic proximity Read ↗

BCR/ABL, DNA damage and DNA repair: Implications for new treatment conceptsSemantic proximity Read ↗

PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway–Deficient Acute Myeloid LeukemiaSemantic proximity Read ↗

Critical role of FANCC in JAK2 V617F mutant-induced resistance to DNA cross-linking drugs.Semantic proximity Read ↗

DNA Damage and DNA Damage Response in Chronic Myeloid LeukemiaSemantic proximity Read ↗

Cytogenetic, fluorescence in situ hybridization, and genomic array characterization of chronic myeloid leukemia with cryptic BCR-ABL1 fusions.Semantic proximity Read ↗

Development and characterization of immortalized fibroblastoid cell lines from an FA(C) mouse model.Semantic proximity Read ↗

Functional and physical interaction between the mismatch repair and FA-BRCA pathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.