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Article

Blood clearance in the rat of a recombinant mouse monoclonal antibody lacking the N-linked oligosaccharide side chains of the CH2 domains.

Molecular immunology - 1 Feb 1992

Wawrzynczak E J, Cumber A J, Parnell G D, Jones P T, Winter G

Abstract excerpt

The serum half-lives of a wild-type recombinant mouse monoclonal antibody of the IgG2b isotype and a mutant antibody differing from the wild-type antibody by a single amino acid substitution introduced into the CH2 domain, the replacement of Asn 297 by Ala to delete the conserved site of heavy chain glycosylation, were determined in the rat. The biological half-life of the aglycosyl Asn 297-Ala mutant recombinant...

Topics

Animals
Antibodies, Monoclonal
Glycoproteins
Glycoside Hydrolases
Glycosylation
Immunoglobulin Constant Regions
Immunoglobulin Heavy Chains
Immunoglobulin Isotypes
Male
Metabolic Clearance Rate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oligosaccharides

Rats

Recombinant Proteins

Source

Identifiers

PMID: 1542298
DOI: 10.1016/0161-5890(92)90102-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1542298-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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