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Article

Mapping the site on human IgG for binding of the MHC class I-related receptor, FcRn

1 Sept 1999

Abstract excerpt

The analysis of the pharmacokinetics of wild-type and mutated Fc fragments derived from human IgG1 indicates that Ile253, His310 and His435 play a central role in regulating serum half-life in mice. Reduced serum half-life of the recombinant, mutated fragments correlates with decreased binding to the MHC class I-related neonatal Fc receptor, FcRn. In addition, the analysis of an Fc fragment in which His435 is...

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Identifiers

PMID: 10508256
DOI: 10.1002/(sici)1521-4141(199909)29:09<2819::aid-immu2819>3.0.co;2-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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