Article
Variations of specific mRNA and polypeptide contents of rat liver D-beta-hydroxybutyrate dehydrogenase during an experimental diabetes mellitus.
Biochimie - 1 May 1990
Bailly A, Lone Y C, Latruffe N
Abstract excerpt
The expression of the rat liver D-beta-hydroxybutyrate dehydrogenase (BDH) gene was investigated at different levels: the level of its specific mRNA, the protein content and the enzymatic activity. By using a cDNA probe, we found that the BDH mRNA was about 2 kb and we report here that the decrease of BDH activity in diabetic rats is due to a reduction in the content of the enzyme, which is proportional to a...
Topics
- Animals
- Diabetes Mellitus, Experimental
- Female
- Gene Expression Regulation, Enzymologic
- Genetic Variation
- Hydroxybutyrate Dehydrogenase
- Insulin
- Liver
- Male
- Rats
- Rats, Inbred Strains