Article
Antigenic analysis of classical swine fever virus E2 glycoprotein using pig antibodies identifies residues contributing to antigenic variation of the vaccine C-strain and group 2 strains circulating in China.
Virology journal - 31 Dec 2010
Chen Ning, Tong Chao, Li Dejiang, Wan Jing, Yuan Xuemei, Li Xiaoliang, Peng Jinrong, Fang Weihuan
Abstract excerpt
BACKGROUND: Glycoprotein E2, the immunodominant protein of classical swine fever virus (CSFV), can induce neutralizing antibodies and confer protective immunity in pigs. Our previous phylogenetic analysis showed that subgroup 2.1 viruses branched away from subgroup 1.1, the vaccine C-strain lineage, and became dominant in China. The E2 glycoproteins of CSFV C-strain and recent subgroup 2.1 field isolates are...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Neutralizing
- Antigenic Variation
- Antigens, Viral
- China
- Classical Swine Fever
- Classical Swine Fever Virus
- Codon
- Escherichia coli
- Genetic Variation
- Immune Sera
- Mutagenesis, Site-Directed