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Combining network modeling and gene expression microarray analysis to explore the dynamics of Th1 and Th2 cell regulation.

PLoS computational biology - 16 Dec 2010

Pedicini Marco, Barrenäs Fredrik, Clancy Trevor, Castiglione Filippo, Hovig Eivind, Kanduri Kartiek, Santoni Daniele, Benson Mikael

Abstract excerpt

Two T helper (Th) cell subsets, namely Th1 and Th2 cells, play an important role in inflammatory diseases. The two subsets are thought to counter-regulate each other, and alterations in their balance result in different diseases. This paradigm has been challenged by recent clinical and experimental data. Because of the large number of genes involved in regulating Th1 and Th2 cells, assessment of this paradigm by...

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PMID: 21187905
DOI: 10.1371/journal.pcbi.1001032
PMCID: PMC3002992

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