Article
miR-29 acts as a decoy in sarcomas to protect the tumor suppressor A20 mRNA from degradation by HuR.
Science signaling - 30 Jul 2013
Balkhi M Y, Balkhi Mumtaz Y, Iwenofu O Hans, Bakkar Nadine, Ladner Katherine J, Chandler Dawn S, Houghton Peter J, London Cheryl A, Kraybill William, Perrotti Danilo, Croce Carlo M, Keller Charles, Guttridge Denis C
Abstract excerpt
In sarcoma, the activity of NF-κB (nuclear factor κB) reduces the abundance of the microRNA (miRNA) miR-29. The tumor suppressor A20 [also known as TNFAIP3 (tumor necrosis factor-α-induced protein 3)] inhibits an upstream activator of NF-κB and is often mutated in lymphomas. In a panel of human s...
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