Article
Cell cycle networks link gene expression dysregulation, mutation, and brain maldevelopment in autistic toddlers.
Molecular systems biology - 14 Dec 2015
Pramparo Tiziano, Lombardo Michael V, Campbell Kathleen, Barnes Cynthia Carter, Marinero Steven, Solso Stephanie, Young Julia, Mayo Maisi, Dale Anders, Ahrens-Barbeau Clelia, Murray Sarah S, Lopez Linda, Lewis Nathan, Pierce Karen, Courchesne Eric
Abstract excerpt
Genetic mechanisms underlying abnormal early neural development in toddlers with Autism Spectrum Disorder (ASD) remain uncertain due to the impossibility of direct brain gene expression measurement during critical periods of early development. Recent findings from a multi-tissue study demonstrated high expression of many of the same gene networks between blood and brain tissues, in particular with cell cycle...
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